The delivery of high-quality, compassionate, holistic and patient-centered care, including end-of-life care, is central to nursing practice. Hallmarks of end-of-life care include respect for patient self-determination, nonjudgmental support for patients’ end-of-life preferences and values, and prevention and alleviation of suffering. In states where medical aid in dying is legal, patient self-determination extends to include a terminally ill patient’s autonomous, voluntary choice and informed request to self-administer medication to hasten death. Medical aid in dying is not synonymous with euthanasia. There is a key distinction between the two terms. Laws that allow medical aid in dying permit an adult patient with a terminal illness and the capacity for medical decision-making to self-administer oral or enteral medication when certain criteria are met. Euthanasia, which is not legal in the United States, occurs when someone other than the patient administers medication in any form with the intention of hastening the patient’s death. Euthanasia is inconsistent with the core commitments of the nursing profession and profoundly violates public trust. The term medical aid in dying will be used in this document. This position statement clarifies the scope of the nursing role in the care of patients who request medical aid in dying, with a particular focus on the Code of Ethics for Nurses with Interpretive Statements’ elucidation of nurses’ ethical obligations and responsibilities regarding this end-of-life option (ANA, 2015a). Nurses are ethically prohibited from administering medical aid in dying medication. Yet they must be comfortable supporting patients with end-of-life conversations, assessing the context of a medical aid in dying request (e.g., concern about treatable depression or coercion), advocating optimized palliative and hospice care services, and knowing about aid in dying laws and how those affect practice. Nurses should reflect on personal values related to medical aid in dying and be aware of how those values inform one’s ability to provide objective information in response to a patient’s request. ANA recognizes that medical aid in dying is a controversial topic that encompasses a plurality of views. Arguments for medical aid in dying are based on respect for patients’ self-determination, a desire to prevent unnecessary suffering, assurance that patients have access to the full range of care options at the end of life, and consideration that medical aid in dying is a last act of autonomy. Arguments against medical aid in dying include the sacredness of life, the potential conflict with professional core values, and fears of a “slippery slope,” where the increased acceptability of medical aid in dying may impact perceptions of a “life worth living” (Olsen, Chan, & Lehto, 2017; Sulmasy et al., 2018).